Senior Thesis

A Structural Model of Genetic Regulatory Networks

  David V. Foster

April 25, 2005

Thesis Committee: Joshua Socolar, Henry Greenside, Ronen Plesser, Calvin Howell  (exofficio non-voting member)

ABSTRACT:  This project studies the structure the relationship between structural and dynamical features of networks. We create a model of network growth based on growth rules inspired by biology, proposed by Socolar and Kauffman. We then use analytical tools as well as simulations to explore the structural properties of networks formed by this model, such as degree distribution and clustering coefficient. Our goal is to see how much biologically plausible structure can be created by simple rules, without the careful crafting of natural selection. We find a broad range of possible behaviors exhibited by our model for different parameter values.  We also explore a measure of the feedback loop structure of networks proposed by Socolar. We believe this measure captures important global features of the network that are essential to its dynamical behavior. We implement an algorithm in Mathematica for measuring this structure and apply it to several different classes of networks. We find that networks formed by preferential attachment produce fewer feedback loops than NK networks.

Here is the thesis in PDF: dfoster_thesis.pdf (about 0.31 MBytes)