Nicolas Buchler

Assistant Professor

Office: 
Rm 2353a, CIEMAS Bldg, 101 Science Drive, Duke Box 3382, Durham, NC 27710
Campus Box: 
3382
Phone: 
(919) 699-8209
Fax: 
(919) 668-0795

Details

Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates.
Molecular biology of the cell (2016)

Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators
Physical Review E (2015)

Different Mechanisms Confer Gradual Control and Memory at Nutrient- and Stress-Regulated Genes in Yeast.
Molecular and cellular biology (2015)

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-component and Metazoan-type Tyrosine Kinase Signaling.
Genome biology and evolution (2015)

Redox rhythm reinforces the circadian clock to gate immune response.
Nature (2015)

Redox rhythm reinforces the circadian clock to gate immune response
Nature (2015)

Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for patterning, cell proliferation, and differentiation in biological systems. We also study biochemical oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources.

Education:
Ph.D. - University of Michigan at Ann Arbor
M.S. - University of Michigan at Ann Arbor
B.S. - University of California at San Diego
2011 NIH Director's New Innovator Award, National Institutes of Health
2006 Career Award at the Scientific Interface, Burroughs Wellcome Funds