Nicolas Buchler

Assistant Professor

Office: 
2353A CIEMAS
Campus Box: 
3382
Phone: 
(919) 699-8209
Fax: 
(919) 668-0795

Details

Programming stress-induced altruistic death in engineered bacteria
Mol Syst Biol (2012)

Evolution of networks and sequences in eukaryotic cell cycle control
Philos Trans R Soc Lond B Biol Sci. (2011)

Chromatin: Bind at your own RSC
Current Biology (2011)

Protein sequestration generates a flexible ultrasensitive response in a genetic network.
Mol Syst Biol (2009)

Molecular titration and ultrasensitivity in regulatory networks.
J Mol Biol (2008)

Designing sequential transcription logic: a simple genetic circuit for conditional memory.
Syst Synth Biol (2007)

Transcriptional regulation by the numbers: models.
Curr Opin Genet Dev (2005)

Transcriptional regulation by the numbers: applications.
Curr Opin Genet Dev (2005)

Two-faced cyclins with eyes on the targets.
Cell Cycle (2005)

Nonlinear protein degradation and the function of genetic circuits.
Proc Natl Acad Sci U S A (2005)

Bistable and oscillatory dynamics in regulatory networks are essential for patterning, cell proliferation, and cell differentiation in biological systems. My lab takes an interdisciplinary approach (theory and experiment; physics and biology; synthetic and systems biology) to understand the diverse molecular and evolutionary mechanisms by which thresholds, combinatorial control, bistability, and oscillation have evolved in biological systems.

Education:
PhD - University of Michigan
BS - University of California, San Diego