Nicolas Buchler

Assistant Professor

Rm 2353a, Ciemas Bldg, 101 Science Drive, Duke Box 3382, Durham, NC 27710
Campus Box: 
(919) 699-8209
(919) 668-0795


Different Mechanisms Confer Gradual Control and Memory at Nutrient- and Stress-Regulated Genes in Yeast.
Molecular and cellular biology (2015)

Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates.
Molecular biology of the cell (2015)

Redox rhythm reinforces the circadian clock to gate immune response.
Nature (2015)

Redox rhythm reinforces the circadian clock to gate immune response
Nature (2015)

Programming stress-induced altruistic death in engineered bacteria.
Molecular Systems Biology (2012)

Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for proper patterning, cell proliferation, and cellular differentiation in biological systems. We also study biochemical oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared chemical and energy resources.

Ph.D. - University of Michigan at Ann Arbor
M.S. - University of Michigan at Ann Arbor
B.S. - University of California at San Diego
2011 NIH Director's New Innovator Award, National Institutes of Health
2006 Career Award at the Scientific Interface, Burroughs Wellcome Funds