Nicolas Buchler

Assistant Professor

Office: 
2353A CIEMAS
Campus Box: 
3382
Phone: 
(919) 699-8209
Fax: 
(919) 668-0795

Details

Redox rhythm reinforces the circadian clock to gate immune response
Nature (2015)

Programming stress-induced altruistic death in engineered bacteria.
Molecular Systems Biology (2012)

Evolution of networks and sequences in eukaryotic cell cycle control.
Philosophical Transactions of the Royal Society of London. Series B, Biological sciences (2011)

Chromatin: bind at your own RSC.
Current biology : CB (2011)

Evolution of networks and sequences in eukaryotic cell cycle control
Philos Trans R Soc Lond B Biol Sci. (2011)

Protein sequestration generates a flexible ultrasensitive response in a genetic network.
Molecular Systems Biology (2009)

Molecular titration and ultrasensitivity in regulatory networks.
Journal of Molecular Biology (2008)

Molecular titration and ultrasensitivity in regulatory networks.
J Mol Biol (2008)

Bistable and oscillatory dynamics in regulatory networks are essential for patterning, cell proliferation, and cell differentiation in biological systems. My lab takes an interdisciplinary approach (theory and experiment; physics and biology; synthetic and systems biology) to understand the diverse molecular and evolutionary mechanisms by which thresholds, combinatorial control, bistability, and oscillation have evolved in biological systems.

Education:
PhD - University of Michigan
BS - University of California, San Diego
2011 NIH Director's New Innovator Award, National Institutes of Health
2006 Career Award at the Scientific Interface, Burroughs Wellcome Funds