Nicolas Buchler

Assistant Professor

Office: 
2353A CIEMAS
Campus Box: 
3382
Phone: 
(919) 699-8209
Fax: 
(919) 668-0795

Details

Protein sequestration generates a flexible ultrasensitive response in a genetic network.
Mol Syst Biol (2009)

Molecular titration and ultrasensitivity in regulatory networks.
Journal of molecular biology (2008)

Molecular titration and ultrasensitivity in regulatory networks.
J Mol Biol (2008)

Designing sequential transcription logic: a simple genetic circuit for conditional memory.
Syst Synth Biol (2007)

Transcriptional regulation by the numbers: models.
Curr Opin Genet Dev (2005)

Transcriptional regulation by the numbers: applications.
Curr Opin Genet Dev (2005)

Two-faced cyclins with eyes on the targets.
Cell Cycle (2005)

Nonlinear protein degradation and the function of genetic circuits.
Proc Natl Acad Sci U S A (2005)

On schemes of combinatorial transcription logic.
Proc Natl Acad Sci U S A (2003)

Surveying determinants of protein structure designability across different energy models and amino-acid alphabets: A consensus
J. Chem. Phys. (2000)

Bistable and oscillatory dynamics in regulatory networks are essential for patterning, cell proliferation, and cell differentiation in biological systems. My lab takes an interdisciplinary approach (theory and experiment; physics and biology; synthetic and systems biology) to understand the diverse molecular and evolutionary mechanisms by which thresholds, combinatorial control, bistability, and oscillation have evolved in biological systems.

Education:
PhD - University of Michigan
BS - University of California, San Diego
2011 NIH Director's New Innovator Award, National Institutes of Health
2006 Career Award at the Scientific Interface, Burroughs Wellcome Funds