Nicolas Buchler

Assistant Professor

Office: 
Rm 2353a, CIEMAS Bldg, 101 Science Drive, Duke Box 3382, Durham, NC 27710
Campus Box: 
3382
Phone: 
(919) 699-8209
Fax: 
(919) 668-0795

Details

Programming stress-induced altruistic death in engineered bacteria.
Molecular Systems Biology (2012)

Evolution of networks and sequences in eukaryotic cell cycle control.
Philosophical Transactions of the Royal Society of London. Series B, Biological sciences (2011)

Evolution of networks and sequences in eukaryotic cell cycle control
Philosophical Transactions of the Royal Society B: Biological Sciences (2011)

Chromatin: Bind at your own RSC
Current Biology (2011)

Chromatin: bind at your own RSC.
Current biology : CB (2011)

Evolution of networks and sequences in eukaryotic cell cycle control
Philos Trans R Soc Lond B Biol Sci. (2011)

Protein sequestration generates a flexible ultrasensitive response in a genetic network
Molecular Systems Biology (2009)

Protein sequestration generates a flexible ultrasensitive response in a genetic network.
Molecular Systems Biology (2009)

Molecular Titration and Ultrasensitivity in Regulatory Networks
Journal of Molecular Biology (2008)

Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for patterning, cell proliferation, and differentiation in biological systems. We also study biochemical oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources.

Education:
Ph.D. - University of Michigan at Ann Arbor
M.S. - University of Michigan at Ann Arbor
B.S. - University of California at San Diego
2011 NIH Director's New Innovator Award, National Institutes of Health
2006 Career Award at the Scientific Interface, Burroughs Wellcome Funds