Bastiaan Driehuys

Associate Research Professor

Associate Professor of Biomedical Engineering

161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Campus Box: 
3302 Med Ctr
(919) 684-7786
(919) 684-7122


3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.
NMR in biomedicine (2014)

Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.
Academic radiology (2014)

Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.
Journal of applied physiology (Bethesda, Md. : 1985) (2014)

Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized (129)Xe.
Physical review. A (2014)

Enabling hyperpolarized 129Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin
Magnetic Resonance in Medicine (2013)

Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease
NMR in Biomedicine (2013)

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Ph.D. - Princeton University