A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized (3)He MRI.
NMR in biomedicine (2015)
Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.
Magnetic resonance imaging (2015)
Hyperpolarized Gas MR Imaging: Technique and Applications.
Magnetic resonance imaging clinics of North America (2015)
Single-breath clinical imaging of hyperpolarized (129) xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.
Magnetic resonance in medicine (2015)
Optimizing 3D noncartesian gridding reconstruction for hyperpolarized 129Xe MRI-focus on preclinical applications
Concepts in Magnetic Resonance Part A: Bridging Education and Research (2015)
Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.
Academic radiology (2014)
3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.
NMR in biomedicine (2014)
Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.
Journal of applied physiology (Bethesda, Md. : 1985) (2014)
Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized (129)Xe.
Physical review. A (2014)
Enabling hyperpolarized 129Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin
Magnetic Resonance in Medicine (2013)
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My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.