Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes.
The journal of physical chemistry. B (2009)
Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe.
A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.
NMR in biomedicine (2009)
Pulmonary Perfusion and Xenon Gas Exchange in Rats: MR Imaging with Intravenous Injection of Hyperpolarized 129Xe.
In vivo MRI using real-time production of hyperpolarized 129Xe.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2008)
An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology.
Proceedings of the American Thoracic Society (2008)
Small animal imaging with magnetic resonance microscopy.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources (2008)
3He MRI in mouse models of asthma.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (2007)
Imaging techniques for small animal models of pulmonary disease: MR microscopy.
Toxicologic pathology (2007)
Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.
Proceedings of the National Academy of Sciences of the United States of America (2006)
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.